Contraindicated (one)pentobarbital will reduce the extent or effect of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.Barbiturates can induce hepatic microsomal enzymes resulting in enhanced metabolism and lowered anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); suffe